Background: Histologic characteristics have proven to be very useful for classifying different types of tumors of the\npancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic\nappearance.\nMain body: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of\ntumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These\nadvances have not only confirmed the traditional histologic classification system, but also opened new doors to\nearly diagnosis and targeted treatment.\nConclusion: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment\ntargets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic\nneuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma
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